Phytochemical analysis and Antidiabestic activity of Withania somnifera and Cnidium monnieri using animal models

Abstract

Type 2 diabetes is one of the most prevalent non- contagious diseases that cause serious complications. The progression of excess weight leads to the increasing incidence among populations of type 2 diabetes mellitus. In form 2 diabetes mellitus instances the median input of obesity is 90%. Moreover, around 174 million individuals worldwide are subject to glucose intolerance, the most prevalent being obesity and metabolic syndrome. There are many therapeutic plants in medical field and out of these Withania somnifera and Cnidium monnieri are effective against many disorders such as, allergy reactions, dermatophytes, many types of bacterial and fungal infections, osteoporotic, weakness, coldness, and skin related disorders. The aim of this study was to check out the hypoglycemic, anti-obesity, cytotoxic and hepatoprotective activities of these two plants. The animals were divided into 7 groups, first group was normal controlled group and second group was intoxicated. Third group was treated with standard drugs Glucophage and Mevastatin. Rats of fourth, fifth, sixth and seventh group was treated with extracts of Withania somnifera and Cnidium monnieri in high and low concentrations. As expecting these both gave positive results showing the significant decrease in body weight led to decrease in insulin level and also had cytotoxic effect that was close to normal value.